解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3127-x
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...
journal_title:Malaria journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12936-019-3090-6
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission. Primaquine has been administered together on the first or the last day of conventional treatment but the impact of primaquine timing has never bee...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-020-3121-3
更新日期:2020-01-21 00:00:00
abstract:BACKGROUND:Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. METHODS:Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quan...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12936-020-3105-3
更新日期:2020-01-15 00:00:00
abstract:BACKGROUND:The intraerythrocytic development cycle (IDC) of the rodent malaria Plasmodium chabaudi is coordinated with host circadian rhythms. When this coordination is disrupted, parasites suffer a 50% reduction in both asexual stages and sexual stage gametocytes over the acute phase of infection. Reduced gametocyte d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3107-1
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Immunization with attenuated malaria sporozoites protects humans from experimental malaria challenge by mosquito bite. Protection in humans is strongly correlated with the production of T cells targeting a heterogeneous population of pre-erythrocyte antigen proteoforms, including liver stage antigens. Curren...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3093-3
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3057-7
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3067-5
更新日期:2019-12-16 00:00:00
abstract::India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-019-3011-8
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:Rhoptries are the large, paired, secretory organelles located at the apical tip of the malaria merozoite that are considered important for parasite invasion processes. Plasmodium vivax rhoptry proteins have been shown to induce humoral immunity during natural infections. Therefore, these proteins may be pote...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3009-2
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria. METHODS:Filter-paper blo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2977-6
更新日期:2019-10-07 00:00:00
abstract:BACKGROUND:Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to the last remaining at-risk places. An evaluation of the performance of surveillance systems in 16 c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2960-2
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China-Myanmar border to provide epidemio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2924-6
更新日期:2019-09-12 00:00:00
abstract::The Global Technical Strategy 2016-2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria transmission, the reservoir of human infection may be intermittently symptomatic or fully silent yet still lea...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2906-8
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-rang...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2910-z
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2905-9
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Modelling risk of malaria in longitudinal studies is common, because individuals are at risk for repeated infections over time. Malaria infections result in acquired immunity to clinical malaria disease. Prospective cohorts are an ideal design to relate the historical exposure to infection and development of...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2885-9
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Measures of malaria burden using microscopy and rapid diagnostic tests (RDTs) in cross-sectional household surveys may incompletely describe the burden of malaria in low-transmission settings. This study describes the pattern of malaria transmission in Ethiopia using serological antibody estimates derived fr...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2874-z
更新日期:2019-07-22 00:00:00
abstract:BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2875-y
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:Agro-ecological systems have been associated with increased malaria intensity. This study determined association between different agro-ecological systems, prevalence of malaria parasitaemia and anaemia in Mvomero district, Tanzania. METHODS:The study was carried out in three agro-ecosystems namely, savanna...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2859-y
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:Slash and burn cultivators are a significant risk group for malaria in South-East Asia. As envisaged in the National Strategic Plan for Malaria Elimination, Bangladesh aims to achieve zero indigenous malaria transmission by 2030. For the national plan to move from malaria control to malaria elimination, targ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2849-0
更新日期:2019-06-25 00:00:00
abstract:BACKGROUND:In a previous study, severe and cerebral malaria have been connected with acute cochlear malfunction in children, demonstrated by a decrease of transitory evoked otoacoustic emissions (TEOAEs) reproducibility. This study aims to determine whether cochlear malfunction persists for 4 years after recovery from ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2840-9
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-019-2806-y
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Malaria is an increasing concern in Indonesia. Socio-demographic factors were found to strongly influence malaria prevalence. This research aimed to explore the associations between socio-demographic factors and malaria prevalence in Indonesia. METHODS:The study used a cross-sectional design and analysed re...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2760-8
更新日期:2019-04-12 00:00:00
abstract:BACKGROUND:Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2759-1
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Malaria is still an important parasitic infectious disease that affecting poor and vulnerable communities in many developing countries, including Indonesia. During the period of 2010-2017, there have been approximately 2.2 million confirmed malaria cases reported across Indonesia. This study aimed to identif...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2758-2
更新日期:2019-04-04 00:00:00
abstract:BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2745-7
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion (GMS). The Plasmodium vivax parasite population has experienced varying drug pressure dependent ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2749-3
更新日期:2019-04-02 00:00:00
abstract::The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as continuous surfaces using model-based geostatistical methods. The opportunities and limitations of these mapped o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2729-7
更新日期:2019-03-22 00:00:00
abstract:BACKGROUND:Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. However, people with glucose-6-phosphate dehydrogenase (G...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2715-0
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Malaria is heterogeneously distributed across landscapes. Human population movement (HPM) could link sub-regions with varying levels of transmission, leading to the persistence of disease even in very low transmission settings. Malaria along the Thai-Myanmar border has been decreasing, but remains heterogene...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2704-3
更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:Malaria is one of the most severe public health issues that result in massive morbidity and mortality in most countries of the sub-Saharan Africa (SSA). This study aimed to determine the scope of household, accessibility to malaria care and factors associated with household malaria in the Democratic Republic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2679-0
更新日期:2019-02-26 00:00:00
abstract:BACKGROUND:Anti-malarial treatments effectiveness remains a critical challenge for control programmes. However, when drug efficacy is established, the dose is calculated based on a predefined weight according to the patient age. Based on the hypothesis that the standard assumption of weight according to the age when ad...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2673-6
更新日期:2019-02-18 00:00:00
abstract:BACKGROUND:Control of vivax malaria in endemic areas requires management of recurrence. The Brazilian National Malaria Surveillance System (SIVEP-Malária) records every case of malaria in Brazil, but is not designed to differentiate between primary and recurrent infections. The aim of this study was to explore whether ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2644-y
更新日期:2019-01-22 00:00:00
abstract:BACKGROUND:A malaria vaccine based on Plasmodium falciparum apical membrane antigen 1 (AMA1) elicited strain specific efficacy in Malian children that waned in the second season after vaccination despite sustained AMA1 antibody titers. With the goal of identifying a humoral correlate of vaccine-induced protection, pre-...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2637-x
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2642-0
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quality anti-malarials directly affect health outcomes by increasing malaria morbidity and mortality, as ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2628-3
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2634-5
更新日期:2019-01-03 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. The aim of this study was to assess the diagnostic performance of salivary urea nitrogen (SUN) dipst...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2627-4
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Congenital malaria is usually defined as the detection of asexual forms of Plasmodium spp. in a blood sample of a neonate during perinatal age if there is no possibility of postpartum infection by a mosquito bite. The incidence of congenital malaria is highly variable and seems related to several factors, su...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2614-9
更新日期:2018-12-14 00:00:00